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1

Discovery and structure–activity study of a novel benzoxaborole anti-inflammatory agent (AN2728) for the potential topical treatment of psoriasis and atopic dermatitis

Tsutomu Akama, Stephen J. Baker, Yong-Kang Zhang, Vincent Hernandez, Huchen Zhou, Virginia Sanders, Yvonne Freund, Richard Kimura, Kirk R. Maples, Jacob J. Plattner

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2009

Langue:

english

Fichier:

PDF, 434 KB

english, 2009

2

Topical treatment for cutaneous leishmaniasis – dermato-pharmacokinetic led optimisation of benzoxaboroles

Van Bocxlaer, Katrien, Gaukel, Eric, Hauser, Deirdre, Park, Seong Hee, Schock, Sara, Yardley, Vanessa, Randolph, Ryan, Plattner, Jacob J., Merchant, Tejal, Croft, Simon L., Jacobs, Robert T., Wring, S

Journal:

Antimicrobial Agents and Chemotherapy

Année:

2018

Langue:

english

Fichier:

PDF, 1.67 MB

english, 2018

3

Synthesis and structure–activity relationships of novel benzoxaboroles as a new class of antimalarial agents

Yong-Kang Zhang, Jacob J. Plattner, Yvonne R. Freund, Eric E. Easom, Yasheen Zhou, Jiri Gut, Philip J. Rosenthal, David Waterson, Francisco-Javier Gamo, Inigo Angulo-Barturen, Min Ge, Zhiya Li, Lingch

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2011

Langue:

english

Fichier:

PDF, 801 KB

english, 2011

4

Synthesis of isotopically labelled [3-14C]- and [3,3-2H2]-5-fluoro-1,3-dihydro-1-hydroxy-2,1-benzoxaborole (AN2690), a new antifungal agent for the potential treatment of onychomycosis

Stephen J. Baker, Yong-Kang Zhang, Tsutomu Akama, Conrad Wheeler, Jacob J. Plattner, Richard M. Rosser, Ronald P. Reid, Neil S. Nixon

Journal:

Journal of Labelled Compounds and Radiopharmaceuticals

Année:

2007

Langue:

english

Fichier:

PDF, 113 KB

english, 2007

5

Synthesis of new acylsulfamoyl benzoxaboroles as potent inhibitors of HCV NS3 protease

Xianfeng Li, Yong-Kang Zhang, Yang Liu, Suoming Zhang, Charles Z. Ding, Yasheen Zhou, Jacob J. Plattner, Stephen J. Baker, Liang Liu, Wei Bu, Wieslaw M. Kazmierski, Lois L. Wright, Gary K. Smith, Rich

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2010

Langue:

english

Fichier:

PDF, 668 KB

english, 2010

6

Synthesis and biological evaluations of P4-benzoxaborole-substituted macrocyclic inhibitors of HCV NS3 protease

Charles Z. Ding, Yong-Kang Zhang, Xianfeng Li, Yang Liu, Suoming Zhang, Yasheen Zhou, Jacob J. Plattner, Stephen J. Baker, Liang Liu, Maosheng Duan, Richard L. Jarvest, Jingjing Ji, Wieslaw M. Kazmier

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2010

Langue:

english

Fichier:

PDF, 663 KB

english, 2010

7

Synthesis and SAR of acyclic HCV NS3 protease inhibitors with novel P4-benzoxaborole moieties

Xianfeng Li, Suoming Zhang, Yong-Kang Zhang, Yang Liu, Charles Z. Ding, Yasheen Zhou, Jacob J. Plattner, Stephen J. Baker, Wei Bu, Liang Liu, Wieslaw M. Kazmierski, Maosheng Duan, Richard M. Grimes, L

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2011

Langue:

english

Fichier:

PDF, 1.21 MB

english, 2011

8

Synthesis and SAR of novel benzoxaboroles as a new class of β-lactamase inhibitors

Yi Xia, Kathy Cao, Yasheen Zhou, M.R.K. Alley, Fernando Rock, Manisha Mohan, Maliwan Meewan, Stephen J. Baker, Sarah Lux, Charles Z. Ding, Guofeng Jia, Maureen Kully, Jacob J. Plattner

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2011

Langue:

english

Fichier:

PDF, 360 KB

english, 2011

9

Synthesis and antiviral activities of the major metabolites of the HIV protease inhibitor ABT-378 (Lopinavir)

Hing L Sham, David A Betebenner, Thomas Herrin, Gondi Kumar, Ayda Saldivar, Sudthida Vasavanonda, Akhter Molla, Dale J Kempf, Jacob J Plattner, Daniel W Norbeck

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2001

Langue:

english

Fichier:

PDF, 127 KB

english, 2001

10

Synthesis and structure–activity relationships of a novel series of HIV-1 protease inhibitors encompassing ABT-378 (Lopinavir)

Hing L. Sham, David A. Betebenner, Xiaoqi Chen, Ayda Saldivar, Sudthida Vasavanonda, Dale J. Kempf, Jacob J. Plattner, Daniel W. Norbeck

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2002

Langue:

english

Fichier:

PDF, 89 KB

english, 2002

11

Benzoxaborole antimalarial agents. Part 3: design and syntheses of (carboxy-13C-3,3-2H2)-labeled and (3-14C)-labeled 7-(2-carboxyethyl)-1,3-dihydro-1-hydroxy-2,1-benzoxaboroles

Yong-Kang Zhang, Jacob J. Plattner, Eric E. Easom, Liang Liu, Daniel M. Retz, Min Ge, Hui-Hong Zhou

Journal:

Journal of Labelled Compounds and Radiopharmaceuticals

Année:

2012

Langue:

english

Fichier:

PDF, 283 KB

english, 2012

12

Benzoxaborole antimalarial agents. Part 2: Discovery of fluoro-substituted 7-(2-carboxyethyl)-1,3-dihydro-1-hydroxy-2,1-benzoxaboroles

Yong-Kang Zhang, Jacob J. Plattner, Yvonne R. Freund, Eric E. Easom, Yasheen Zhou, Long Ye, Huchen Zhou, David Waterson, Francisco-Javier Gamo, Laura M. Sanz, Min Ge, Zhiya Li, Lingchao Li, Hailong Wa

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2012

Langue:

english

Fichier:

PDF, 848 KB

english, 2012

13

Synthesis of novel benzoxaborole-containing phenylalanine analogues

Xianfeng Li, Jacob J. Plattner, Vincent Hernandez, Charles Z. Ding, Wei Wu, Yang Yang, Musheng Xu

Journal:

Tetrahedron Letters

Année:

2011

Langue:

english

Fichier:

PDF, 363 KB

english, 2011

14

Benzoxaboroles: a new class of potential drugs for human African trypanosomiasis

Jacobs, Robert T, Plattner, Jacob J, Nare, Bakela, Wring, Stephen A, Chen, Daitao, Freund, Yvonne, Gaukel, Eric G, Orr, Matthew D, Perales, Joe B, Jenks, Matthew

Journal:

Future Medicinal Chemistry

Année:

2011

Langue:

english

Fichier:

PDF, 2.10 MB

english, 2011

15

Crystal Structures of the Human and Fungal Cytosolic Leucyl-tRNA Synthetase Editing Domains: A Structural Basis for the Rational Design of Antifungal Benzoxaboroles

Elena Seiradake, Weimin Mao, Vincent Hernandez, Stephen J. Baker, Jacob J. Plattner, M.R.K. Alley, Stephen Cusack

Journal:

Journal of Molecular Biology

Année:

2009

Langue:

english

Fichier:

PDF, 1.86 MB

english, 2009

16

An efficient synthesis for a new class antimalarial agent, 7-(2-carboxyethyl)-1,3-dihydro-1-hydroxy-2,1-benzoxaborole

Yong-Kang Zhang, Jacob J. Plattner, Eric E. Easom, David Waterson, Min Ge, Zhiya Li, Lingchao Li, Yong Jian

Journal:

Tetrahedron Letters

Année:

2011

Langue:

english

Fichier:

PDF, 313 KB

english, 2011

17

Discovery of a New Boron-Containing Antifungal Agent, 5-Fluoro-1,3-dihydro-1-hydroxy-2,1- benzoxaborole (AN2690), for the Potential Treatment of Onychomycosis

Baker, Stephen J., Zhang, Yong-Kang, Akama, Tsutomu, Lau, Agnes, Zhou, Huchen, Hernandez, Vincent, Mao, Weimin, Alley, M. R. K., Sanders, Virginia, Plattner, Jacob J.

Journal:

Journal of Medicinal Chemistry

Année:

2006

Langue:

english

Fichier:

PDF, 66 KB

english, 2006

18

[IEEE 2011 IEEE International Conference on Data Engineering (ICDE 2011) - Hannover, Germany (2011.04.11-2011.04.16)] 2011 IEEE 27th International Conference on Data Engineering - Predicting in-memory database performance for automating cluster management tasks

Schaffner, Jan, Eckart, Benjamin, Jacobs, Dean, Schwarz, Christian, Plattner, Hasso, Zeier, Alexander

Année:

2011

Langue:

english

Fichier:

PDF, 279 KB

english, 2011

19

Benzoxaborole Antimalarial Agents. Part 4. Discovery of Potent 6-(2-(Alkoxycarbonyl)pyrazinyl-5-oxy)-1,3-dihydro-1-hydroxy-2,1-benzoxaboroles

Zhang, Yong-Kang, Plattner, Jacob J., Easom, Eric E., Jacobs, Robert T., Guo, Denghui, Sanders, Virginia, Freund, Yvonne R., Campo, Brice, Rosenthal, Philip J., Bu, Wei, Gamo, Francisco-Javier, Sanz,

Journal:

Journal of Medicinal Chemistry

Année:

2015

Langue:

english

Fichier:

PDF, 653 KB

english, 2015

20

Discovery of an orally bioavailable isoxazoline benzoxaborole (AN8030) as a long acting animal ectoparasiticide

Zhang, Yong-Kang, Plattner, Jacob J., Easom, Eric E., Zhou, Yasheen, Akama, Tsutomu, Bu, Wei, White, W. Hunter, Defauw, Jean M., Winkle, Joseph R., Balko, Terry W., Guo, Shenghai, Xue, Jian, Cao, Jian

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2015

Langue:

english

Fichier:

PDF, 624 KB

english, 2015

21

Optimization of Isoxazoline Amide Benzoxaboroles for Identification of a Development Candidate as an Oral Long Acting Animal Ectoparasiticide

Zhang, Yong-Kang, Plattner, Jacob J., Easom, Eric E., Akama, Tsutomu, Zhou, Yasheen, Hunter White, W., Defauw, Jean M., Winkle, Joseph R., Balko, Terry W., Cao, Jianxin, Ge, Zhixin, Yang, Jianzhang

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2016

Langue:

english

Fichier:

PDF, 761 KB

english, 2016

22

Benzoxaborole Antimalarial Agents. Part 5. Lead Optimization of Novel Amide Pyrazinyloxy Benzoxaboroles and Identification of a Preclinical Candidate

Zhang, Yong-Kang, Plattner, Jacob J., Easom, Eric E., Jacobs, Robert T., Guo, Denghui, Freund, Yvonne R., Berry, Pamela, Ciaravino, Vic, Erve, John C. L., Rosenthal, Philip J., Campo, Brice, Gamo, Fra

Journal:

Journal of Medicinal Chemistry

Année:

2017

Langue:

english

Fichier:

PDF, 1.23 MB

english, 2017

23

Identification of a 4-fluorobenzyl l -valinate amide benzoxaborole ( AN11736 ) as a potential development candidate for the treatment of Animal African Trypanosomiasis (AAT)

Akama, Tsutomu, Zhang, Yong-Kang, Freund, Yvonne R., Berry, Pamela, Lee, Joanne, Easom, Eric E., Jacobs, Robert T., Plattner, Jacob J., Witty, Michael J., Peter, Rosemary, Rowan, Tim G., Gillingwater,

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2017

Langue:

english

Fichier:

PDF, 981 KB

english, 2017

24

ChemInform Abstract: Motilides and Motilactides: Design and Development of Motilin Receptor Agonists as a New Class of Gastrointestinal Prokinetic Drugs

Ramin Faghih, Hugh N. Nellans, Jacob J. Plattner

Journal:

Année:

1999

Fichier:

PDF, 25 KB

1999

25

ChemInform Abstract: Synthesis and Structure—Activity Relationships of a Novel Series of HIV-1 Protease Inhibitors Encompassing ABT-378 (Lopinavir).

Hing L. Sham, David A. Betebenner, Xiaoqi Chen, Ayda Saldivar, Sudthida Vasavanonda, Dale J. Kempf, Jacob J. Plattner, Daniel W. Norbeck

Journal:

Année:

2002

Langue:

english

Fichier:

PDF, 32 KB

english, 2002

26

Novel Lopinavir Analogues Incorporating Non-aromatic P-1 Side Chains — Synthesis and Structure—Activity Relationships.

Hing L. Sham, Chen Zhao, Leping Li, David A. Betebenner, Ayda Saldivar, Sudthida Vasavanonda, Dale J. Kempf, Jacob J. Plattner, Daniel W. Norbeck

Journal:

Année:

2003

Fichier:

PDF, 147 KB

2003

27

Novel Lopinavir Analogues Incorporating Heterocyclic Replacements of Six-Member Cyclic Urea. Synthesis and Structure—Activity Relationships.

Hing L. Sham, David A. Betebenner, William Rosenbrook, Thomas Herrin, Ayda Saldivar, Sudthida Vasavanonda, Jacob J. Plattner, Daniel W. Norbeck

Journal:

Année:

2004

Fichier:

PDF, 70 KB

2004

28

ChemInform Abstract: Discovery and Structure—Activity Study of a Novel Benzoxaborole Antiinflammatory Agent (AN2728) for the Potential Topical Treatment of Psoriasis and Atopic Dermatitis.

Tsutomu Akama, Stephen J. Baker, Yong-Kang Zhang, Vincent Hernandez, Huchen Zhou, Virginia Sanders, Yvonne Freund, Richard Kimura, Kirk R. Maples, Jacob J. Plattner

Journal:

Année:

2009

Fichier:

PDF, 21 KB

2009

29

Effects of purine nucleoside analogues with a cyclobutane ring and erythromycin A oxime derivatives on duck hepatitis B virus replication in vivo and in cell culture and HIV-1 in cell culture

Li-Fang Hung, Amy E. Brumbaugh, Gulshan Bhatia, Patricia L. Marion, Paul P. Hung, Daniel W. Norbeck, Jacob J. Plattner, William S. Robinson

Journal:

Journal of Medical Virology

Année:

1991

Langue:

english

Fichier:

PDF, 650 KB

english, 1991

30

In Vitro penetration of a novel oxaborole antifungal (AN2690) into the human nail plate

Xiaoying Hui, Stephen J. Baker, Ronald C. Wester, Sherry Barbadillo, Anne K. Cashmore, Virginia Sanders, Karin M. Hold, Tsutomu Akama, Yong-Kang Zhang, Jacob J. Plattner, Howard I. Maibach

Journal:

Journal of Pharmaceutical Sciences

Année:

2007

Langue:

english

Fichier:

PDF, 195 KB

english, 2007

31

A practical stereoselective synthesis of (2S, 4S)-4-tert-butoxycarbonylamino-2-methylpyrrolidine

Qun Li, Daniel T.W. Chu, Kathleen Raye, Akiyo Claiborne, Louis Seif, Bryan Macri, Jacob J. Plattner

Journal:

Tetrahedron Letters

Année:

1995

Langue:

english

Fichier:

PDF, 314 KB

english, 1995

32

Design and synthesis of boron-containing PDE4 inhibitors using soft-drug strategy for potential dermatologic anti-inflammatory application

Yong-Kang Zhang, Jacob J. Plattner, Tsutomu Akama, Stephen J. Baker, Vincent S. Hernandez, Virginia Sanders, Yvonne Freund, Richard Kimura, Wei Bu, Karin M. Hold, Xiao-Song Lu

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2010

Langue:

english

Fichier:

PDF, 642 KB

english, 2010

33

Synthesis and antibacterial activity of novel C12 ethyl ketolides

Matthew T. Burger, Christy Hiebert, Mehran Seid, Daniel T. Chu, Lynn Barker, Mike Langhorne, Ribhi Shawar, Jolene Kidney, Manoj C. Desai, Jacob J. Plattner

Journal:

Bioorganic & Medicinal Chemistry

Année:

2006

Langue:

english

Fichier:

PDF, 287 KB

english, 2006

34

Corrigendum to “Synthesis and antiviral activities of the major metabolites of the HIV protease inhibitor ABT-378 (Lopinavir)”: [Bioorg. Med. Chem. Lett. 11 (2001) 1351]

Hing L. Sham, David A. Betebenner, Thomas Herrin, Gondi Kumar, Ayda Saldivar, Sudthida Vasavanonda, Akhter Molla, Dale J. Kempf, Jacob J. Plattner, Daniel W. Norbeck

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2004

Fichier:

PDF, 204 KB

2004

35

Synthesis and antibacterial activity of C12 des-methyl ketolides

Xiaodong Lin, Alice C. Rico, Daniel T. Chu, Georgia L. Carroll, Lynn Barker, Ribhi Shawar, Manoj C. Desai, Jacob J. Plattner

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2006

Langue:

english

Fichier:

PDF, 142 KB

english, 2006

36

Identification of a novel boron-containing antibacterial agent (AN0128) with anti-inflammatory activity, for the potential treatment of cutaneous diseases

Stephen J. Baker, Tsutomu Akama, Yong-Kang Zhang, Vittorio Sauro, Chetan Pandit, Rajeshwar Singh, Maureen Kully, Jehangir Khan, Jacob J. Plattner, Stephen J. Benkovic, Ving Lee, Kirk R. Maples

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2006

Langue:

english

Fichier:

PDF, 143 KB

english, 2006

37

Synthesis and evaluation of novel α-amino cyclic boronates as inhibitors of HCV NS3 protease

Xianfeng Li, Yong-Kang Zhang, Yang Liu, Charles Z. Ding, Qun Li, Yasheen Zhou, Jacob J. Plattner, Stephen J. Baker, Xuelei Qian, Dazhong Fan, Liang Liao, Zhi-Jie Ni, Gemma V. White, Jackie E. Mordaunt

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2010

Langue:

english

Fichier:

PDF, 1.37 MB

english, 2010

38

Novel macrocyclic HCV NS3 protease inhibitors derived from α-amino cyclic boronates

Xianfeng Li, Yong-Kang Zhang, Yang Liu, Charles Z. Ding, Yasheen Zhou, Qun Li, Jacob J. Plattner, Stephen J. Baker, Suoming Zhang, Wieslaw M. Kazmierski, Lois L. Wright, Gary K. Smith, Richard M. Grim

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2010

Langue:

english

Fichier:

PDF, 1.13 MB

english, 2010

39

Synthesis of 9-deoxotaxane analogs

Larry L. Klein, Clinton M. Yeung, Leping Li, Jacob J. Plattner

Journal:

Tetrahedron Letters

Année:

1994

Langue:

english

Fichier:

PDF, 266 KB

english, 1994

40

Antifungal rapamycin analogues with reduced immunosuppressive activity

Daniel A Dickman, Hong Ding, Qun Li, Angela M Nilius, Darlene J Balli, Stephen J Ballaron, James M Trevillyan, Morey L Smith, Louis S Seif, Ki Kim, Aparna Sarthy, Robert C Goldman, Jacob J Plattner, Y

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2000

Langue:

english

Fichier:

PDF, 107 KB

english, 2000

41

C-3′-N-acyl analogs of 9(R)-dihydrotaxol: synthesis and structure activity relationships

Clarence J. Maring, David J. Grampovnik, Clinton M. Yeung, Larry l. Klein, Leping Li, Sheela A. Thomas, Jacob J. Plattner

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

1994

Langue:

english

Fichier:

PDF, 287 KB

english, 1994

42

In vivo characterization of A-192411: a novel fungicidal lipopeptide (II)

Jonathan A Meulbroek, Angela M Nilius, Qun Li, Weibo Wang, Lisa Hasvold, Beth Steiner, Daniel A Dickman, Hong Ding, David Frost, Robert C Goldman, Paul Lartey, Jacob J Plattner, Youssef L Bennani

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2003

Langue:

english

Fichier:

PDF, 115 KB

english, 2003

43

Novel 3-deoxy-3-descladinosyl-6-O-methyl erythromycin a analogues. Synthesis and in vitro activity

Richard L. Elliott, Daisy Pireh, Angela M. Nilius, Pauline M. Johnson, Robert K. Flamm, Daniel T.W. Chu, Jacob J. Plattner, Yat Sun Or

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

1997

Langue:

english

Fichier:

PDF, 307 KB

english, 1997

44

Preparation of 9-deoxo-4″-deoxy-6,9-epoxyerythromycin lactams “motilactides”: Potent and orally active prokinetic agents

Ramin Faghih, Hugh N. Nellans, Paul A. Lartey, Albert Petersen, Kennan Marsh, Youssef L. Bennani, Jacob J. Plattner

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

1998

Langue:

english

Fichier:

PDF, 271 KB

english, 1998

45

Highly efficient synthesis of 2(S)-3(R,S)-2-amino-4,4-difluoro-1,6-diphenyl-3-hydroxyhexane — the key intermediate for a series of potent HIV proteinase inhibitors

Hing L. Sham, David A. Betebenner, Norman E. Wideburg, Dale J. Kempf, Jacob J. Plattner, Daniel W. Norbeck

Journal:

Journal of Fluorine Chemistry

Année:

1995

Langue:

english

Fichier:

PDF, 332 KB

english, 1995

46

Novel lopinavir analogues incorporating heterocyclic replacements of six-member cyclic urea––synthesis and structure–activity relationships

Hing L. Sham, David A. Betebenner, William Rosenbrook, Thomas Herrin, Ayda Saldivar, Sudthida Vasavanonda, Jacob J. Plattner, Daniel W. Norbeck

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2004

Langue:

english

Fichier:

PDF, 271 KB

english, 2004

47

Novel lopinavir analogues incorporating non-Aromatic P-1 side chains—Synthesis and structure–Activity relationships

Hing L Sham, Chen Zhao, Leping Li, David A Betebenner, Ayda Saldivar, Sudthida Vasavanonda, Dale J Kempf, Jacob J Plattner, Daniel W Norbeck

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2002

Langue:

english

Fichier:

PDF, 98 KB

english, 2002

48

Profile of the Renin Inhibitor, Enalkiren (ABBOTT-64662)

Hollis D. Kleinert, Jay R. Luly, Barbara A. Bopp, Kenneth M. Verburg, Patricia A. Hoyos, Michael D. Karol, Jacob J. Plattner, Robert R. Luther, Herman H. Stein

Journal:

Cardiovascular Therapeutics

Année:

1990

Langue:

english

Fichier:

PDF, 1.35 MB

english, 1990

49

N-(Methanesulfonyl)-16-phenoxyprostaglandin carboxamides: tissue-selective, uterine stimulants

Schaaf, Thomas K., Bindra, Jasjit S., Eggler, James F., Plattner, Jacob J., Nelson, A. James, Johnson, M. Ross, Constantine, Jay W., Hess, Hans-Juergen, Elger, Walter

Journal:

Journal of Medicinal Chemistry

Année:

1981

Langue:

english

Fichier:

PDF, 927 KB

english, 1981

50

Synthesis of (2S,5S,4R)-2,5-diamino-3,3-difluoro-1,6-diphenylhydroxyhexane: the core unit of a potent HIV proteinase inhibitor

Sham, Hing L., Wideburg, Norman E., Spanton, Stephen G., Kohlbrenner, William E., Betebenner, David. A., Kempf, Dale J., Norbeck, Daniel W., Plattner, Jacob J., Erickson, John W.

Journal:

Journal of the Chemical Society Chemical Communications

Année:

1991

Langue:

english

Fichier:

PDF, 222 KB

english, 1991